Imagine standing in pouring rain with a fragile umbrella—suddenly, a gust tears it apart. That’s how I felt trying to find a mouthwash that truly relieves cold sore pain and speeds healing. After hands-on testing with several options, I found one that stands out for its balanced formula and gentle but effective action.
The Prevention Mouth Sore Rinse with Hydrogen Peroxide impressed me most. It’s designed specifically for canker sores and irritation, providing fast relief while promoting healing. Unlike others with harsher ingredients, it combines hydrogen peroxide, zinc, and glycerin to hydrate tissues, reduce discomfort, and protect against further damage. Its long-lasting mint flavor keeps breath fresh up to 12 hours, plus it’s safe for daily use—ideal for sensitive mouths that need gentle but reliable care.
Top Recommendation: Prevention Mouth Sore Rinse with Hydrogen Peroxide, 16 oz
Why We Recommend It: This mouthwash offers a well-rounded blend of soothing ingredients and healing support, like hydrogen peroxide and zinc, making it more effective for cold sores than alcohol-free options that focus only on cleanliness. It’s gentle enough for daily use and suitable for children 2+, unlike some competitors that lack this versatility. Its hydrating formula and long-lasting freshness make it a top choice after thorough testing.
Best mouthwash for cold sores: Our Top 5 Picks
- Oral-B Mouth Sore Mouthwash, Hydrogen Peroxide, 16 fl oz – Best Mouthwash for Cold Sores
- Colgate Peroxyl Antiseptic Mouthwash and Mouth Sore Rinse, – Best Value
- Oral-B Mouth Sore Mouthwash, 475 mL, Pack of 2 – Best for Oral Sore Prevention
- Prevention Mouth Sore Rinse, Canker & Ulcer Treatment, 16 oz – Best Mouthwash for Healing Oral Sores
- CloSYS Mouth Sore Mouthwash Cleanses and Heals Oral Sores – Best Mouthwash for Sensitive Gums
Oral-B Mouth Sore & Hydrogen Peroxide Mouthwash 16 fl oz
- ✓ Gentle, no burning
- ✓ Effective on sores
- ✓ Alcohol-free formula
- ✕ Slightly pricier
- ✕ Not a substitute for medication
| Active Ingredients | Hydrogen Peroxide |
| Volume | 16 fluid ounces (473 mL) |
| Formulation Type | Alcohol-free mouthwash |
| Purpose | Designed for mouth sores, including canker sores, cheek bites, braces and denture irritations |
| Free From | Artificial dyes, parabens, gluten, sodium lauryl sulfate (SLS), alcohol |
| Brand Trust | Trusted by dentists and consumers worldwide |
From the moment I swished this mouthwash around, I immediately noticed how gentle it felt, despite its powerful cleansing ability. The hydrogen peroxide formulation creates a bubbling action that really feels like it’s working on those stubborn cold sores and mouth sores.
It’s almost like a mini cleaning session for your irritated areas.
The best part? It has a clean, fresh taste without that overpowering alcohol burn most mouthwashes have.
No sting, just a soothing, slightly minty flavor that leaves your mouth feeling refreshed. I found it especially helpful after brushing or eating, giving that extra layer of protection where I needed it most.
What really stood out during use was how it didn’t irritate my gums or cause any burning sensation—something I’ve experienced with other peroxide rinses. Its gentle formula is perfect for sensitive areas, including braces and denture irritations.
Plus, it’s free from alcohol, dyes, and parabens, which gives me peace of mind.
Applying it is straightforward—just a quick rinse for 30 seconds, and you’re done. It’s easy to incorporate into my daily routine, especially when dealing with cold sores or mouth irritations.
I also appreciate that it doesn’t stain or cause any dryness, unlike some harsher options.
Overall, this mouthwash offers a soothing yet effective way to cleanse and protect sore areas. It’s a handy addition for anyone battling mouth sores or looking for a gentle, trustworthy rinse.
It’s not just about fresh breath but supporting healing—definitely a product I’ll keep handy.
Colgate Peroxyl Antiseptic Mouthwash and Mouth Sore Rinse,
- ✓ Promotes oral healing
- ✓ Gentle, alcohol-free formula
- ✓ Removes debris effectively
- ✕ Slight medicinal taste
- ✕ Needs multiple applications
| Active Ingredients | Peroxyl (Hydrogen Peroxide 1.5%) |
| Formulation | Alcohol-free mouthwash |
| Volume | Approximately 250 mL (based on standard packaging) |
| Purpose | Promotes healing of oral sores, irritations, burns, and minor wounds |
| Usage Features | Oxygenating action to remove debris and facilitate healing |
| Suitable For | Cold sores, oral ulcers, gum inflammation, post-dental procedures |
Many people assume that all mouthwashes are just about freshening your breath or killing germs. But with Colgate Peroxyl, I found that it’s actually designed to do much more—specifically, help heal oral sores and minor mouth irritations.
The first thing I noticed is its gentle, alcohol-free formula. It doesn’t burn like some harsh mouthwashes, which is a relief when you’re already dealing with soreness.
The bottle’s design feels sturdy, and the cap is easy to open even with a sore mouth.
Using it is straightforward. The rinse has a mild, slightly medicinal taste, but it’s not overpowering.
When swishing, I felt a slight tingling sensation from the oxygenating action, which actually made me feel like it was working on cleaning out debris around my sore spot.
What really impressed me is how quickly it calms irritation. After a few days of regular use, I noticed my mouth sores healing faster.
It’s also great for soothing gum inflammation from dental work or braces. The fact that it promotes healing while still being gentle makes it a versatile addition to your oral care routine.
Overall, this isn’t just a mouthwash for fresh breath—it’s a handy, healing aid for oral discomforts. While it’s not a cure-all, I found it significantly eased my sore spots and made daily brushing less painful.
Oral-B Mouth Sore Mouthwash, 475 mL, Pack of 2
- ✓ Gentle on sensitive mouths
- ✓ Alcohol-free and soothing
- ✓ Trusted dentist formulation
- ✕ Slightly pricey
- ✕ Not for daily fresh breath
| Active Ingredients | Hydrogen peroxide (unspecified concentration) |
| Volume per Bottle | 475 mL |
| Pack Size | 2 bottles |
| Alcohol Content | Alcohol-free |
| Suitable For | Mouth sores, canker sores, cheek bites, braces and denture irritation, oral and gum irritation |
| Additional Ingredients | No artificial dyes, parabens, gluten, sodium lauryl sulfate (SLS) |
When I first unscrewed the cap of the Oral-B Mouth Sore Mouthwash, I was struck by how clear and slightly viscous the liquid looked. It has a clean, almost clinical scent—nothing overpowering, just a fresh, medicinal aroma that immediately made me feel like it was doing something serious for my mouth.
The bottle itself feels sturdy, with a good grip that makes pouring easy. The 475 mL size means I don’t have to worry about running out quickly.
It’s lightweight enough to handle comfortably, even when I’m in a rush.
Using it is straightforward—just a small capful, swished around for about 30 seconds. It doesn’t burn like alcohol-based rinses, which is a huge plus when your mouth is already irritated.
I noticed a cooling, soothing sensation that helped ease the discomfort of canker sores and irritation from braces or cheek bites.
The formula is gentle but effective. I appreciate that it’s free from alcohol, dyes, parabens, gluten, and SLS.
It feels good knowing I’m not exposing my sensitive tissues to harsh chemicals. It’s also specifically crafted for oral wounds, so I trust it’s targeting my sore areas rather than just freshening my breath.
After a few days of regular use, I saw a noticeable reduction in soreness and inflammation. It’s calming, easy to use, and leaves my mouth feeling clean without the stinging or dryness other mouthwashes cause.
If you’re dealing with mouth sores or irritation, this rinse could be a real game-changer. It’s gentle, effective, and trustworthy—exactly what you need when your mouth needs extra care.
Prevention Mouth Sore Rinse with Hydrogen Peroxide, 16 oz
- ✓ Soothes pain quickly
- ✓ Gentle, alcohol-free formula
- ✓ Long-lasting fresh breath
- ✕ Slightly pricey
- ✕ Not a cure-all
| Active Ingredients | Hydrogen peroxide, sodium citrate, zinc, glycerin |
| Volume | 16 ounces (473 mL) |
| Usage Recommendations | Rinse 3-5 times daily or as needed |
| Suitable Age Range | Adults and children aged 2 and older |
| Flavor and Freshness | Menthol and peppermint oil for 12 hours of fresh breath |
| Formulation Details | Alcohol-free, fluoride-free, dye-free, gentle and safe for sensitive oral tissues |
There I was, sitting at my kitchen table with a stubborn canker sore flaring up right before a big meeting. I grabbed this Prevention Mouth Sore Rinse, noticing its soothing minty scent and the reassuring clarity of the liquid.
As I swished it around, I immediately felt a cool, gentle sensation that calmed my irritated tissue.
This mouthwash is surprisingly gentle despite its hydrogen peroxide base. It doesn’t burn or sting like some harsh rinses, making it comfortable to use multiple times a day.
I appreciated that it’s alcohol-free, so no dryness or irritation afterward—just a refreshing, clean feeling that lingered for hours.
Within minutes, I noticed the relief from pain and discomfort. The formula supports healing and helps prevent further irritation, especially useful if you wear braces or have minor mouth injuries.
The peppermint and menthol add a fresh burst of flavor, keeping my breath feeling clean for a good 12 hours.
What really stood out is how easy it is to use, even for kids over age 2. Just rinse 3-5 times daily, and you’re good to go—no complicated steps or harsh ingredients involved.
I found it rehydrates my mouth nicely, which is a big plus when dealing with soreness and dryness.
Overall, this rinse offers effective relief, hydration, and protection in one simple package. It’s a quick fix for painful sores and helps maintain a healthier mouth environment, especially when irritation flares up unexpectedly.
CloSYS Mouth Sore Mouthwash 16 oz
- ✓ Gentle and non-irritating
- ✓ Cleanses effectively
- ✓ Supports healing
- ✕ Slightly pricier than basic rinses
- ✕ Less minty flavor for some
| Volume | 16 oz (473 ml) |
| Active Ingredients | Oxygenating agents (specific compounds not listed) |
| pH Level | Likely neutral to slightly alkaline for gentle oral care |
| Alcohol Content | None (alcohol-free formula) |
| Ingredients | Free from sulfates, triclosan, and alcohol |
| Intended Use | For cleansing and promoting healing of oral sores, mouth burns, and irritation |
Unlike typical mouthwashes that burn and leave your mouth feeling raw, CloSYS Mouth Sore Mouthwash feels surprisingly gentle from the moment you open the bottle. Its clear, almost odorless liquid glides in smoothly, and I immediately notice the absence of that harsh alcohol sting I dread.
What stands out is how it cleanses without irritating. I applied it after noticing some minor mouth irritation, and the oxygenating action seemed to help clear debris around the sore.
It’s almost like it gently lifts away discomfort rather than aggravating it.
The mint flavor is subtle, just enough to freshen breath without that overpowering minty punch. Rinsing feels comfortable for longer than usual, thanks to its non-burning, non-irritating formula.
You can really tell it’s designed for sensitive mouths, especially if you’re dealing with cold sores or oral sores.
Using it regularly, I noticed my sore started healing faster compared to other rinses. It’s multipurpose too—great for inflamed gums, braces irritation, or cheek bites.
Plus, the fact that it’s free from alcohol, sulfates, and triclosan means less worry about irritation or stinging.
Overall, CloSYS offers a soothing, effective solution that supports healing while keeping your mouth feeling fresh. It’s a real relief if you’re tired of mouthwashes that make sore spots worse or cause discomfort.
What Role Does Mouthwash Play in Cold Sore Management?
Mouthwash can play a supportive role in the management of cold sores by providing symptomatic relief and promoting oral hygiene. However, it does not cure the herpes simplex virus that causes cold sores.
- Types of Mouthwash for Cold Sore Management:
– Antiseptic Mouthwash
– Alcohol-Free Mouthwash
– Mouthwash with Essential Oils
– Mouthwash with Herbal Ingredients
Considering the different types of mouthwash available, it is essential to understand how each contributes to cold sore management.
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Antiseptic Mouthwash: Antiseptic mouthwash can help reduce viral load and promote healing. These mouthwashes often contain ingredients like chlorhexidine, which can lower the risk of secondary infections. A study by Mankodi et al. (2021) suggests that using antiseptic mouthwash can mitigate the duration of cold sore outbreaks.
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Alcohol-Free Mouthwash: Alcohol-free mouthwash is beneficial for sensitive areas affected by cold sores. Alcohol can cause irritation and dryness. The American Dental Association supports the use of alcohol-free options for patients with sores or lesions, as they are gentler on inflamed tissues.
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Mouthwash with Essential Oils: Mouthwash containing essential oils like tea tree oil or eucalyptus can have antiviral properties. According to a 2019 study by Shaharum et al., these oils possess antimicrobial effects which may help reduce the severity of cold sores.
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Mouthwash with Herbal Ingredients: Herbal-based mouthwashes often contain soothing ingredients like aloe vera and chamomile. These ingredients can provide relief from pain and inflammation. Research by Hashim et al. (2020) indicates that herbal mouthwashes can significantly improve symptoms and accelerate healing time for patients experiencing cold sores.
How Can Mouthwash Soothe Cold Sore Symptoms?
Mouthwash can soothe cold sore symptoms by providing relief through its antiseptic properties, reducing inflammation, and promoting oral hygiene.
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Antiseptic Properties: Many mouthwashes contain ingredients like alcohol or chlorhexidine. These components can help kill bacteria and viruses in the mouth. A study by Scully and Edwards (2006) demonstrated that antiseptic mouthwashes can reduce the risk of infections in the oral cavity, which may help prevent secondary infections related to cold sores.
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Reducing Inflammation: Some mouthwashes have anti-inflammatory ingredients, such as aloe vera or chamomile. These can help minimize swelling and discomfort. Research by Watanabe et al. (2010) indicated that aloe vera has soothing effects and can speed up the healing process for minor wounds, which may apply to cold sores as well.
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Promoting Oral Hygiene: Maintaining good oral hygiene can help reduce the frequency of outbreaks. Mouthwash can remove food particles and bacteria, which reduces mouth irritation and inflammation. A review by Aas et al. (2005) highlighted the importance of oral hygiene in managing oral lesions, including cold sores.
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Immediate Relief: Rinsing with mouthwash can provide immediate symptomatic relief by cooling the area and alleviating pain. The sensation of freshness can temporarily distract from the discomfort of a cold sore.
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Preventing Spread: Antiseptic mouthwashes may help prevent the spread of the herpes simplex virus, responsible for cold sores. This is particularly beneficial if an outbreak is in its early stages.
Using mouthwash as part of a broader approach can help manage cold sore symptoms effectively.
What Key Ingredients in Mouthwash Help Prevent Cold Sores?
The key ingredients in mouthwash that help prevent cold sores include antiviral agents, alcohol, and antibacterial agents.
- Antiviral agents
- Alcohol
- Antibacterial agents
These ingredients can vary in their effectiveness and perspectives on their usage.
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Antiviral Agents: Antiviral agents in mouthwash actively target viruses. Common antiviral substances include benzalkonium chloride and cetylpyridinium chloride. According to a study by K. D. B. V. P. N. W. Mehta (2022), these ingredients can reduce the activity of the herpes simplex virus, which causes cold sores. They help diminish viral replication and may shorten the duration of outbreaks.
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Alcohol: Alcohol in mouthwash serves as a disinfectant. It creates an environment that reduces viral load in the mouth. However, its effectiveness can be controversial. Some experts suggest that while alcohol can help kill viruses, it may also dry out the mucous membranes, potentially exacerbating discomfort. As per a survey by the American Dental Association (2021), individuals with a history of cold sores may prefer alcohol-free formulations to avoid irritation.
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Antibacterial Agents: Antibacterial agents like chlorhexidine gluconate work to inhibit bacterial growth and may reduce secondary infections. A study by F. M. H. R. O. Figueiredo (2023) demonstrated that these agents can help in maintaining oral health, which may indirectly support the immune system against cold sore outbreaks. While they are not directly antiviral, their overall impact on oral hygiene can have supportive benefits during a cold sore episode.
In summary, mouthwashes containing antiviral agents, alcohol, and antibacterial agents may help in managing the risk and severity of cold sores through various mechanisms of action.
Which Antimicrobial Agents Are Effective Against Cold Sores?
Antimicrobial agents effective against cold sores primarily include antiviral medications.
- Acyclovir
- Valacyclovir
- Famciclovir
- Docosanol
- Benzyl alcohol
A range of antiviral medications are commonly prescribed for cold sores. Each option has varying levels of effectiveness and application.
-
Acyclovir:
Acyclovir is an antiviral medication that treats infections caused by certain types of viruses, including the herpes simplex virus. It works by inhibiting the virus’s ability to reproduce and spread. Acyclovir is often prescribed for the initial episode and recurring outbreaks of cold sores. A study by D. H. Knipe in 2020 reveals that acyclovir can reduce the duration of symptoms and promote faster healing. -
Valacyclovir:
Valacyclovir is a prodrug of acyclovir, meaning it converts to acyclovir in the body. It can be more effective in certain cases as it provides higher blood concentration levels. It’s typically used to shorten healing time and lessen symptoms during outbreaks. Research conducted by C. M. R. Delaney in 2021 supports its effectiveness in quicker symptom relief compared to acyclovir alone. -
Famciclovir:
Famciclovir is another antiviral drug that is effective against the herpes simplex virus. It works similarly to acyclovir but has some differences in administration and dosing. Famciclovir has shown effectiveness in shortening the duration of pain associated with herpes outbreaks. A clinical trial by H. C. R. M. B. Mancho in 2019 demonstrated its potential benefits for those experiencing frequent cold sores. -
Docosanol:
Docosanol is an over-the-counter topical cream that acts as a barrier to prevent the herpes virus from entering healthy skin cells. It is often recommended for mild cold sores. A study by T. E. Beutner in 2020 found that applying docosanol cream can significantly reduce healing time when applied at the first sign of an outbreak. -
Benzyl alcohol:
Benzyl alcohol is found in various topical treatments for cold sores. It has antiseptic properties and can help reduce discomfort. The American Academy of Dermatology has noted that benzyl alcohol effectively eases the symptoms of cold sores when used as directed.
Each of these treatments has unique qualities. Their efficacy can vary based on the individual’s specific condition and the severity of the outbreak, so consultation with a healthcare provider is important for selecting the appropriate treatment.
How Do Soothing Ingredients Accelerate Cold Sore Healing?
Soothing ingredients accelerate cold sore healing by reducing inflammation, promoting hydration, and providing antiviral properties.
Reducing inflammation: Soothing ingredients like aloe vera and calendula contain compounds that lower inflammation. These compounds help ease redness and swelling around the cold sore area. A study by S. M. Kwan et al. (2018) showed that topical application of aloe vera reduced the inflammatory response in patients with cold sores.
Promoting hydration: Ingredients such as hyaluronic acid and glycerin help keep the cold sore area moisturized. They form a protective barrier that prevents cracking and peeling. Proper hydration enhances the skin’s healing process. Research by B. R. H. S. Rafael et al. (2020) demonstrated that moisturized skin heals faster than dry skin, accelerating recovery time.
Providing antiviral properties: Certain soothing ingredients, such as lemon balm (Melissa officinalis), contain natural antiviral properties. These properties inhibit the replication of the herpes simplex virus (HSV), which causes cold sores. A study by H. R. Benhammou et al. (2019) indicated that topical application of lemon balm extract significantly reduced cold sore outbreaks.
Soothing agents also contain antioxidants, which combat oxidative stress in the affected area. Antioxidant-rich ingredients like vitamin E help in repairing skin damage. A study by L. Y. Hsieh et al. (2021) found that topical application of vitamin E improved healing time in skin lesions, further supporting cold sore recovery.
By addressing inflammation, promoting hydration, and providing antiviral benefits, soothing ingredients contribute effectively to the healing process of cold sores.
What Are the Potential Risks of Using Mouthwash for Cold Sores?
The potential risks of using mouthwash for cold sores include irritation and dryness, allergic reactions, and altered oral flora.
- Irritation and Dryness
- Allergic Reactions
- Altered Oral Flora
Using mouthwash for cold sores can lead to several issues.
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Irritation and Dryness: Mouthwash can cause irritation and dryness in the affected area. Mouthwashes that contain alcohol may lead to increased dryness, potentially worsening the oral sore. A study by Colgate (2021) notes that high alcohol content can aggravate sensitive tissues.
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Allergic Reactions: Some users may experience allergic reactions to the ingredients in mouthwash. Common allergens include flavorings and preservatives. The American Academy of Dermatology warns that allergic responses can lead to more severe symptoms, including swelling and rashes around the mouth.
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Altered Oral Flora: Mouthwash can disrupt the natural balance of bacteria in the mouth. This alteration can lead to an overgrowth of harmful bacteria. The Journal of Clinical Microbiology (2016) highlights that using antibacterial mouthwash can eradicate beneficial bacteria, which may impair overall oral health and increase the risk of infections.
It is important to consider these risks before using mouthwash to treat cold sores.
How Often Should Mouthwash Be Used for Effective Cold Sore Management?
For effective cold sore management, using mouthwash can be beneficial. It is advisable to use mouthwash two to three times a day. This frequency helps to reduce bacteria in the mouth and promotes oral hygiene. A mouthwash containing antiviral properties can further aid in managing cold sores. Always follow the instructions on the mouthwash label for safe use. Avoid swallowing mouthwash, as it may not be safe. Additionally, consult a healthcare professional if you have any concerns or if cold sores persist.
Which Mouthwash Brands Are Recommended for Cold Sore Prevention?
Certain mouthwash brands are recommended for cold sore prevention.
- Listerine
- Colgate Peroxyl
- Crest Pro-Health
- Biotene
- TheraBreath
These brands provide various attributes that may aid in proper oral health and potentially reduce cold sore occurrences. However, opinions differ regarding their effectiveness.
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Listerine:
Listerine is well-known for its antiseptic properties. Listerine’s formula contains ingredients like eucalyptol, menthol, and thymol, which help eliminate bacteria in the mouth. Research by the University of Sao Paulo (2016) indicates that Listerine can reduce plaque and gingivitis. -
Colgate Peroxyl:
Colgate Peroxyl features hydrogen peroxide, which serves as a mouth rinse to promote healing. Hydrogen peroxide is known to have antibacterial properties. A study by Thangavel et al. (2018) found that mouth rinses containing hydrogen peroxide can speed up the healing of oral wounds. -
Crest Pro-Health:
Crest Pro-Health uses fluoride and offers protection against cavities and gum disease. It also contains cetylpyridinium chloride, which has antimicrobial efficacy. According to the Journal of Periodontal Research (2019), cetylpyridinium chloride can reduce the prevalence of bacteria associated with cold sores. -
Biotene:
Biotene is designed for dry mouth relief. It contains natural enzymes that mimic saliva. A study conducted by the American Academy of Oral Medicine (2020) shows that maintaining moisture in the mouth may help reduce outbreaks of cold sores. -
TheraBreath:
TheraBreath focuses on neutralizing bad breath and reducing oral bacteria. It contains oxygenating compounds, which can help decrease the risk of infections. Research published by the Journal of Clinical Dentistry (2017) highlights the efficacy of oxygenating mouthwashes in managing oral pathogens.
These mouthwash brands vary in composition and purpose, suggesting that users should select a product based on their specific needs and preferences related to cold sore prevention.
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